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1. (WO2018064315) STEM CELL BIOMIMETIC MICROPARTICLES
PCT Biblio. Data
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Claims
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Pub. No.:
WO/2018/064315
International Application No.:
PCT/US2017/053982
Publication Date:
05.04.2018
International Filing Date:
28.09.2017
IPC:
A61K 9/10
(2006.01),
A61K 38/18
(2006.01),
A61K 47/34
(2017.01),
C12N 5/0775
(2010.01),
C07K 14/475
(2006.01)
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C
CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
C
CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
Applicants:
NORTH CAROLINA STATE UNIVERSITY
[US/US]; Office Of Technology Commercialization & New Ventures 1021 Main Campus Drive, 2nd Floor Raleigh, NC 27606 (US)
Inventors:
CHENG, Ke
; (US).
TANG, Junnan
; (US)
Agent:
HAYZER, David, J.
; (US).
THOMAS HORSTEMEYER LLP
; (US)
Priority Data:
62/401,272
29.09.2016
US
62/405,411
07.10.2016
US
Title
(EN)
STEM CELL BIOMIMETIC MICROPARTICLES
(FR)
MICROPARTICULES BIOMIMÉTIQUES DE CELLULES SOUCHES
Abstract:
(EN)
Provided are stern cell biomimetic microparticles comprised of at least one stem cell- derived paracrine polypeptide or growth factor embedded in a polymer core particle that further comprises an outer layer of at Ieast one fragment of a cell membrane of a stem cell disposed on the core particle. The polymer core may be constituted of any biocompatible and biodegradable polymer or copolymer, or a combination thereof that allows the embedding of the paracrine factors and their prolonged release from the core. The core and hence the microparticles can be biodegradable, allowing eventual elimination from the recipient animal or human subject. The core particles are sized to allow both transport through blood vessels and extravasation from the blood vessels into the surrounding tissues. The core particle may further include at least one polypeptide or peptide growth factor to induce the generation and proliferation of a population of stem cells.
(FR)
La présente invention concerne des microparticules biomimétiques de cellules souches comprenant au moins un polypeptide paracrine dérivé de cellules souches ou un facteur de croissance enchâssé dans une particule formant noyau polymère qui comprend en outre une couche externe d’au moins un fragment d’une membrane cellulaire d’une cellule souche disposée sur la particule noyau. Le noyau polymère peut être constitué de n’importe quel polymère ou copolymère biocompatible et biodégradable, ou d’une combinaison de ceux-ci qui permet l’incorporation des facteurs paracrines et leur libération prolongée depuis le noyau. Le noyau et de là les microparticules peuvent être biodégradables, permettant l’élimination éventuelle depuis l’animal ou le sujet humain bénéficiaire. Les particules formant noyau sont dimensionnées pour permettre à la fois le transport à travers les vaisseaux sanguins et l’extravasation depuis les vaisseaux sanguins dans les tissus environnants. La particule formant noyau peut en outre comprendre au moins un facteur de croissance polypeptidique ou peptidique afin d’induire la production et la prolifération d’une population de cellules souches.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)