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1. (WO2018064315) STEM CELL BIOMIMETIC MICROPARTICLES

Pub. No.:    WO/2018/064315    International Application No.:    PCT/US2017/053982
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: A61K 9/10
A61K 38/18
A61K 47/34
C12N 5/0775
C07K 14/475
Applicants: NORTH CAROLINA STATE UNIVERSITY
Inventors: CHENG, Ke
TANG, Junnan
Title: STEM CELL BIOMIMETIC MICROPARTICLES
Abstract:
Provided are stern cell biomimetic microparticles comprised of at least one stem cell- derived paracrine polypeptide or growth factor embedded in a polymer core particle that further comprises an outer layer of at Ieast one fragment of a cell membrane of a stem cell disposed on the core particle. The polymer core may be constituted of any biocompatible and biodegradable polymer or copolymer, or a combination thereof that allows the embedding of the paracrine factors and their prolonged release from the core. The core and hence the microparticles can be biodegradable, allowing eventual elimination from the recipient animal or human subject. The core particles are sized to allow both transport through blood vessels and extravasation from the blood vessels into the surrounding tissues. The core particle may further include at least one polypeptide or peptide growth factor to induce the generation and proliferation of a population of stem cells.