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1. (WO2018064013) METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF β2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR

Pub. No.:    WO/2018/064013    International Application No.:    PCT/US2017/053370
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Wed Sep 27 01:59:59 CEST 2017
IPC: G01N 33/574
C07K 16/28
G01N 33/92
Applicants: ONCOLOGIE, INC.
Inventors: TANG, Min
SHAN, Joseph, S.
KING, Steven, W.
CHANG, Connie
BROWN, Michael, A.
Title: METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF β2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR
Abstract:
Disclosed are surprising new methods and kits for identifying and treating patients treatable with PS-targeting antibodies, particularly for identifying and treating cancer patients using bavituximab and bavituximab combination therapies. The methods and kits are based on the surprising finding that defined ranges of pre-treatment blood concentrations of β2-glycoprotein 1 (β2GΡΙ), particularly functional β2GPI, act as an indicator to accurately predict patients with better treatment outcomes.