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1. (WO2018063216) DUAL COMPARTMENT CAPSULE FOR THE ADMINISTRATION OF ORLISTAT

Pub. No.:    WO/2018/063216    International Application No.:    PCT/US2016/054342
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 30 01:59:59 CEST 2016
IPC: A61K 9/48
A61K 31/335
A61K 31/337
A61K 31/365
A61K 33/44
Applicants: M PHARMACEUTICAL USA INC.
Inventors: THOMPSON, Ronald, J.
THOMPSON, James, M.
Title: DUAL COMPARTMENT CAPSULE FOR THE ADMINISTRATION OF ORLISTAT
Abstract:
A delivery device and method for treating the adverse effects of ingested Orlistat, which includes a capsule providing for the sequential release of different active pharmaceutical ingredients into different regions of the gastrointestinal tract, while maintaining the effectiveness of the ingredients. The capsule typically includes a non-enteric or gastric dissolving compartment and an enteric or intestine-dissolving compartment. The non-enteric compartment dissolves and releases its contents into the stomach, and can include an effective amount of Orlistat and an effective amount of simethicone. The enteric dissolving compartment can include an effective amount of activated charcoal and is not dissolved in the stomach, rather dissolving and releasing its contents into the intestines. The release of activated charcoal only after passing through the stomach and duodenum allows Orlistat and simethicone to be pharmaceutically active and effective prior to the release of the charcoal.