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1. (WO2018062978) NOVEL HETEROARYL COMPOUND, ENANTIOMER, DIASTEREOMER OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
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Pub. No.:    WO/2018/062978    International Application No.:    PCT/KR2017/011091
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
C07D 271/113 (2006.01), C07D 285/135 (2006.01), C07D 249/08 (2006.01), C07D 413/06 (2006.01), C07D 417/06 (2006.01), C07D 403/06 (2006.01), A23L 33/10 (2016.01), A01N 43/50 (2006.01), C11D 3/48 (2006.01)
Applicants: INSTITUT PASTEUR KOREA [KR/KR]; 16, Daewangpangyo-ro 712beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13488 (KR)
Inventors: MIN, Ji Young; (KR).
CHANG, So Young; (KR).
LEE, Ji Hye; (KR).
KANG, Sun Hee; (KR).
KONG, Sun Ju; (KR).
JO, Su Yeon; (KR).
PARK, Kaapjoo; (KR).
KIM, Young Mi; (KR).
CHOI, Junghwan; (KR)
Agent: PHIL & ONZI INT'L PATENT & LAW FIRM; 3F., 36, Seochojungang-ro, Seocho-gu, Seoul 06643 (KR)
Priority Data:
10-2016-0126997 30.09.2016 KR
Title (EN) NOVEL HETEROARYL COMPOUND, ENANTIOMER, DIASTEREOMER OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
(FR) NOUVEAU COMPOSÉ HÉTÉROARYLE, ÉNANTIOMÈRE, DIASTÉRÉOISOMÈRE OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, ET COMPOSITION ANTIVIRALE LE CONTENANT EN TANT QUE PRINCIPE ACTIF
(KO) 신규 헤테로아릴 화합물, 이의 거울상 이성질체, 부분 입체 이성질체 또는 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 항바이러스용 조성물
Abstract: front page image
(EN)The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds represented by formula (I) or formula (II) according to the present invention are remarkably superior in antiviral activity against an influenza virus, and furthermore, have low cytotoxicity and thus low adverse effects on a human body. Therefore, a pharmaceutical composition containing the same as an active ingredient can be effectively used for the prevention or treatment of diseases caused by an influenza virus infection.
(FR)La présente invention concerne un nouveau composé hétéroaryle, un énantiomère, un diastéréoisomère ou un sel pharmaceutiquement acceptable de celui-ci, et une composition antivirale le comprenant en tant que principe actif. Les nouveaux composés représentés par la formule (I) ou la formule (II) selon la présente invention ont une activité antivirale remarquablement supérieure contre un virus de la grippe, et présentent en outre une faible cytotoxicité et donc de faibles effets secondaires sur un corps humain. Par conséquent, une composition pharmaceutique contenant le composé de l'invention en tant que principe actif, peut être utilisée efficacement pour la prévention ou le traitement de maladies provoquées par une infection par le virus de la grippe.
(KO)본 발명은 신규 헤테로아릴 화합물, 이의 거울상 이성질체, 부분 입체 이성질체 또는 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 항바이러스용 조성물에 관한 것이다. 본 발명에 따른 화학식 1 또는 화학식 2로 표시되는 신규한 화합물은 인플루엔자 바이러스에 대한 항바이러스 활성이 현저히 우수할 뿐만 아니라, 세포독성이 낮아 인체에 부작용이 적으므로, 이를 유효성분으로 함유하는 약학적 조성물은 인플루엔자 바이러스 감염에 의해 발병되는 질환의 예방 또는 치료에 유용하게 사용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)