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1. (WO2018062740) TUMOR-SPECIFIC ONCOLYTIC ADENOVIRUS EXPRESSING SMAD3 EPSM PROTEIN

Pub. No.:    WO/2018/062740    International Application No.:    PCT/KR2017/010173
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Tue Sep 19 01:59:59 CEST 2017
IPC: C12N 7/00
A61K 35/76
A61K 38/18
Applicants: AICT (ADVANCED INSTITUTES OF CONVERGENCE TECHNOLOGY)
재단법인 차세대융합기술연구원
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
한양대학교 산학협력단
Inventors: KIM, Seong-Jin
김성진
YANG, Kyung-Min
양경민
PARK, Jinah
박진아
YUN, Chae-Ok
윤채옥
YOON, A-Rum
윤아름
Title: TUMOR-SPECIFIC ONCOLYTIC ADENOVIRUS EXPRESSING SMAD3 EPSM PROTEIN
Abstract:
The present invention relates to an oncolytic virus comprising a polynucleotide for coding a polypeptide in which any one or more among the 179th, 204th, 208th, and 213th amino acid residues in an amino acid sequence of SEQ ID NO: 1 is substituted by another amino acid residue. In addition, the present invention relates to a pharmaceutical composition comprising the oncolytic virus and a pharmaceutically acceptable carrier. Moreover, the present invention relates to a method for killing tumor cells, the method comprising a step of infecting the tumor cells by contacting the tumor cells with the oncolytic virus.