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1. (WO2018062413) NUCLEIC-ACID-CONTAINING LIPID NANOPARTICLES
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Pub. No.: WO/2018/062413 International Application No.: PCT/JP2017/035302
Publication Date: 05.04.2018 International Filing Date: 28.09.2017
IPC:
C12N 15/113 (2010.01) ,A61K 9/127 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 47/04 (2006.01) ,A61K 47/12 (2006.01) ,A61K 47/18 (2006.01) ,A61K 48/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
04
Non-metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
協和発酵キリン株式会社 KYOWA HAKKO KIRIN CO., LTD. [JP/JP]; 東京都千代田区大手町一丁目6番1号 1-6-1, Otemachi, Chiyoda-ku, Tokyo 1008185, JP
Inventors:
畑中 剣太朗 HATANAKA, Kentaro; JP
細江 慎太郎 HOSOE, Shintaro; JP
藪内 隼人 YABUUCHI, Hayato; JP
八木 香機 YAGI, Kaori; JP
Agent:
稲葉 良幸 INABA, Yoshiyuki; JP
大貫 敏史 ONUKI, Toshifumi; JP
Priority Data:
2016-19045928.09.2016JP
Title (EN) NUCLEIC-ACID-CONTAINING LIPID NANOPARTICLES
(FR) NANOPARTICULES LIPIDIQUES COMPRENANT UN ACIDE NUCLÉIQUE
(JA) 核酸含有脂質ナノ粒子
Abstract:
(EN) The present invention provides: nucleic-acid-containing lipid nanoparticles that include a lipid (lipid A) having a hydrophilic moiety that has one quaternary ammonium group and having three independently optionally substituted hydrocarbon groups, a lipid (lipid B) including, in the same molecule, a hydrophilic moiety that has one optionally substituted amino group or one quaternary ammonium group and a hydrophobic moiety that has two independently optionally substituted hydrocarbon groups, a lipid derivative or a fatty acid derivative of a water-soluble polymer, and a nucleic acid; and a method, etc., for producing said lipid nanoparticles.
(FR) L’invention fournit des nanoparticules lipidiques comprenant un acide nucléique qui contiennent : des lipides (lipides A) qui possèdent une partie hydrophile possédant un groupe ammonium quaternaire, et trois groupes hydrocarbure indépendants pouvant être substitués ; des lipides (lipides B) qui contiennent à l’intérieur d’une même molécule une partie hydropile possédant un groupe ammonium quaternaire ou un groupe amino pouvant être substitué, et une partie hydrophobe possédant deux groupes hydrocarbure indépendants pouvant être substitués ; un dérivé d’acide gras ou un dérivé de lipide d’un polymère hydrosoluble ; et un acide nucléique. L’invention fournit également un procédé de fabrication de ces nanoparticules lipidiques comprenant un acide nucléique, ou similaire.
(JA) 本発明は、1つの4級アンモニウム基を有する親水部および置換されていても良い独立した3つの炭化水素基を有する脂質(脂質A)、置換されていても良い1つのアミノ基または1つの4級アンモニウム基を有する親水部および置換されていても良い独立した2つの炭化水素基を有する疎水部を同一分子内に含む脂質(脂質B)、水溶性高分子の脂質誘導体または脂肪酸誘導体、ならびに核酸を含む、核酸含有脂質ナノ粒子、および該脂質ナノ粒子の製造方法等を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)