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1. (WO2018062392) DOWN SYNDROME MODEL RAT AND METHOD FOR PRODUCING SAME
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Pub. No.: WO/2018/062392 International Application No.: PCT/JP2017/035236
Publication Date: 05.04.2018 International Filing Date: 28.09.2017
IPC:
A01K 67/027 (2006.01) ,C12N 15/09 (2006.01) ,C12N 5/10 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants:
国立大学法人鳥取大学 NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY [JP/JP]; 鳥取県鳥取市湖山町南4丁目101番地 4-101, Koyamacho-Minami, Tottori-shi, Tottori 6808550, JP
株式会社Trans Chromosomics TRANS CHROMOSOMICS, INC. [JP/JP]; 鳥取県米子市西町86番地 86, Nishi-cho, Yonago-shi, Tottori 6838503, JP
Inventors:
香月 康宏 KAZUKI Yasuhiro; JP
押村 光雄 OSHIMURA Mitsuo; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2016-19042228.09.2016JP
Title (EN) DOWN SYNDROME MODEL RAT AND METHOD FOR PRODUCING SAME
(FR) RAT DE MODÈLE DU SYNDROME DE DOWN ET SON PROCÉDÉ DE PRODUCTION
(JA) ダウン症モデルラット及びその作製法
Abstract:
(EN) The present application provides: a Down syndrome model rat characterized in that a rat gene homologous with at least one gene located on human chromosome 21 or a fragment thereof is a trisomy and can be passed to offspring, or a Down syndrome model rat characterized in that an exogeneous rat chromosome that carries human chromosome 21 or a fragment thereof or carries a rat gene homologous with human chromosome 21 or a fragment thereof, or a fragment of said exogeneous rat chromosome is included, and at least one gene located on the human chromosome 21 or a fragment thereof or said exogeneous rat chromosome or a fragment thereof and an endogenous rat gene homologous with said gene together form a trisomy and can be passed to offspring; and a method for producing said Down syndrome model rat.
(FR) La présente invention concerne : un rat de modèle du syndrome de Down caractérisé en ce qu’un gène de rat homologue à au moins un gène situé sur le chromosome humain (21) ou son fragment est une trisomie et peut être transmis à son descendant, ou un rat de modèle du syndrome de Down caractérisé en ce qu’un chromosome de rat exogène qui porte le chromosome humain (21) ou son fragment ou qui porte un gène de rat homologue au chromosome humain (21) ou son fragment, ou un fragment dudit chromosome de rat exogène est incorporé, et au moins un gène situé sur le chromosome humain (21) ou son fragment ou ledit chromosome de rat exogène ou son fragment et un gène de rat endogène homologue audit gène conjointement forment une trisomie et peuvent être transmis à un descendant ; et un procédé de production dudit rat de modèle du syndrome de Down.
(JA) この出願は、ヒト21番染色体もしくはその断片上の少なくとも1つの遺伝子と相同なラット遺伝子がトリソミーである、かつ、子孫伝達可能であることを特徴とするダウン症モデルラット、或いは、ヒト21番染色体もしくはその断片、又はヒト21番染色体もしくはその断片と相同なラット遺伝子が存在する外因性ラット染色体もしくはその断片、を含み、前記ヒト21番染色体もしくはその断片又は外因性ラット染色体もしくはその断片上の少なくとも1つの遺伝子と、当該遺伝子と相同な内因性ラット遺伝子とが加わりトリソミーである、かつ、子孫伝達可能であることを特徴とするダウン症モデルラット、並びに、上記ダウン症モデルラットの作製方法を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)