Search International and National Patent Collections

1. (WO2018062361) METHOD FOR DETERMINING ONSET RISK OF SPORADIC COLON CANCER

Pub. No.:    WO/2018/062361    International Application No.:    PCT/JP2017/035137
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: C12Q 1/68
C12N 15/09
Applicants: HANUMAT CO., LTD.
有限会社ハヌマット
EA PHARMA CO., LTD.
EAファーマ株式会社
Inventors: KUSUNOKI Masato
楠 正人
TOIYAMA Yuji
問山 裕二
MITSUI Akira
三井 彰
TAKEHANA Kenji
竹鼻 健司
UMEZAWA Tsutomu
梅澤 努
Title: METHOD FOR DETERMINING ONSET RISK OF SPORADIC COLON CANCER
Abstract:
The present invention provides a method for determining the onset risk of sporadic colon caner, said method comprising a measurement step for measuring the methylation ratios of one or more CpG sites present in specific variable methylation regions in DNA which is recovered from a biological sample collected from a human subject, and a determination step for determining the onset risk of sporadic colon cancer in the human subject on the basis of the average methylation ratio of the variable methylation regions which is calculated using the measured methylation ratios and preset standard values or a preset multivariate discriminant, wherein: the standard values are set respectively for the methylation ratios of the individual variable methylation regions in order to discriminate a sporadic colon cancer patient from a non-sporadic colon cancer patient; and the multivariate discriminant includes, as a variant, the average methylation ratio of one or more variable methylation regions among the specific variable methylation regions.