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|1. (WO2018062361) METHOD FOR DETERMINING ONSET RISK OF SPORADIC COLON CANCER|
|Applicants:||HANUMAT CO., LTD.
EA PHARMA CO., LTD.
|Title:||METHOD FOR DETERMINING ONSET RISK OF SPORADIC COLON CANCER|
The present invention provides a method for determining the onset risk of sporadic colon caner, said method comprising a measurement step for measuring the methylation ratios of one or more CpG sites present in specific variable methylation regions in DNA which is recovered from a biological sample collected from a human subject, and a determination step for determining the onset risk of sporadic colon cancer in the human subject on the basis of the average methylation ratio of the variable methylation regions which is calculated using the measured methylation ratios and preset standard values or a preset multivariate discriminant, wherein: the standard values are set respectively for the methylation ratios of the individual variable methylation regions in order to discriminate a sporadic colon cancer patient from a non-sporadic colon cancer patient; and the multivariate discriminant includes, as a variant, the average methylation ratio of one or more variable methylation regions among the specific variable methylation regions.