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1. (WO2018062225) GENE EXPRESSION PROMOTOR FOR BIFIDOBACTERIUM GENUS BACTERIA
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Pub. No.: WO/2018/062225 International Application No.: PCT/JP2017/034854
Publication Date: 05.04.2018 International Filing Date: 27.09.2017
IPC:
C12N 15/09 (2006.01) ,C12N 1/21 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
Applicants:
株式会社アネロファーマ・サイエンス ANAEROPHARMA SCIENCE, INC. [JP/JP]; 東京都千代田区神田神保町1-103 東京パークタワー201 Tokyo Park Tower 201, 1-103 Kanda Jinbocho, Chiyoda-ku, Tokyo 1010051, JP
Inventors:
鈴木 徹 SUZUKI, Tohru; JP
片岡 之郎 KATAOKA, Shiro; JP
小酒井 智也 KOZAKAI, Tomoya; JP
Agent:
廣田 雅紀 HIROTA, Masanori; JP
Priority Data:
2016-18966128.09.2016JP
Title (EN) GENE EXPRESSION PROMOTOR FOR BIFIDOBACTERIUM GENUS BACTERIA
(FR) PROMOTEUR D'EXPRESSION GÉNIQUE POUR BACTÉRIES DU GENRE BIFIDOBACTERIUM
(JA) ビフィドバクテリウム属細菌の遺伝子発現用プロモーター
Abstract:
(EN) The present invention addresses the problem of providing a promotor capable of efficiently expressing genes, in Bifidobacterium genus bacteria. In the present invention, a promotor including a TTGNNN motif and a TATANT motif located downstream of the TTGNNN motif, preferably a promotor including a TTGTGC motif and a TATAAT motif located 11 or 17 bases downstream from the TTGTGC motif, is used as a gene expression promotor for Bifidobacterium genus bacteria.
(FR) Le problème à la base de la présente invention concerne un promoteur capable d'exprimer efficacement des gènes dans des bactéries du genre Bifidobacterium. Dans la présente invention, un promoteur comprenant un motif TTGNNN et un motif TATANT situé en aval du motif TTGNNN, de préférence un promoteur comprenant un motif TTGTGC et un motif TATAAT situé à 11 ou 17 bases en aval du motif TTGTGC, est utilisé en tant que promoteur d'expression génique pour des bactéries du genre Bifidobacterium.
(JA) ビフィドバクテリウム属細菌中で、遺伝子を効率よく発現することができるプロモーターを提供することを課題とし、TTGNNNモチーフと、該TTGNNNモチーフの下流に配置されたTATANTモチーフとを含むプロモーター、好ましくは、TTGTGCモチーフと、該TTGTGCモチーフの下流11又は17塩基長の位置に配置されたTATAATモチーフを含むプロモーターを、ビフィドバクテリウム属細菌の遺伝子発現用プロモーターとして用いる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)