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1. (WO2018060926) BETA-LACTAMASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/060926    International Application No.:    PCT/IB2017/055973
Publication Date: 05.04.2018 International Filing Date: 28.09.2017
IPC:
C07D 519/06 (2006.01), A61K 31/535 (2006.01), A61P 31/04 (2006.01), C07D 471/18 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel (CH)
Inventors: CASAREZ, Anthony; (US).
FUREGATI, Markus; (CH).
KOCH, Guido; (CH).
LIN, Xiaodong; (US).
OSSOLA, Flavio; (CH).
RECK, Folkert; (US).
SIMMONS, Robert Lowell; (US).
ZHU, Qingming; (US)
Agent: NOVARTIS AG; Lichtstrasse 35 4056 Basel (CH)
Priority Data:
62/401,022 28.09.2016 US
Title (EN) BETA-LACTAMASE INHIBITORS
(FR) INHIBITEURS DE BÊTA-LACTAMASES
Abstract: front page image
(EN)This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
(FR)La présente invention concerne de manière générale des composés de formule (A), tels que décrits ici, qui agissent en tant qu'inhibiteurs de bêta-lactamase, et des sels, des formes cristallines et des formulations de ceux-ci. Dans certains aspects, l'invention concerne des procédés d'utilisation de tels composés en combinaison avec un antibiotique bêta-lactame pour traiter des infections provoquées par des bactéries à Gram négatif, y compris des souches résistantes aux médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)