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1. (WO2018060926) BETA-LACTAMASE INHIBITORS

Pub. No.:    WO/2018/060926    International Application No.:    PCT/IB2017/055973
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: C07D 519/06
A61K 31/535
A61P 31/04
C07D 471/18
Applicants: NOVARTIS AG
Inventors: CASAREZ, Anthony
FUREGATI, Markus
KOCH, Guido
LIN, Xiaodong
OSSOLA, Flavio
RECK, Folkert
SIMMONS, Robert Lowell
ZHU, Qingming
Title: BETA-LACTAMASE INHIBITORS
Abstract:
This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.