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1. (WO2018060691) CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/060691    International Application No.:    PCT/GB2017/052882
Publication Date: 05.04.2018 International Filing Date: 27.09.2017
IPC:
C07D 401/14 (2006.01), C07D 413/14 (2006.01), C07D 401/04 (2006.01), C07D 413/04 (2006.01), C07D 471/04 (2006.01), C07D 471/14 (2006.01), A61K 31/445 (2006.01), A61K 31/5377 (2006.01), A61P 35/00 (2006.01)
Applicants: MISSION THERAPEUTICS LIMITED [GB/GB]; Moneta (Building 280) Babraham Research Campus Cambridge Cambridgeshire CB22 3AT (GB)
Inventors: STOCKLEY, Martin Lee; (GB).
KEMP, Mark Ian; (GB)
Agent: STRATAGEM INTELLECTUAL PROPERTY MANAGEMENT LIMITED; Meridian Court Comberton Road Toft Cambridge Cambridgeshire CB23 2RY (GB)
Priority Data:
1616511.0 29.09.2016 GB
Title (EN) CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30
(FR) HÉTÉROCYCLES CYANO-SUBSTITUÉS AYANT UNE ACTIVITÉ EN TANT QU'INHIBITEURS DE L'USP 30
Abstract: front page image
(EN)The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (I)
(FR)La présente invention concerne une classe d'hétérocycles cyano-substitués de formule (I) ayant une activité en tant qu'inhibiteurs d'enzymes de désubiquilation, en particulier, l'hydrolase 30 C-terminale ubiquitine ou la peptidase 30 spécifique de l'ubiquitine (USP30), ayant une utilité dans une variété de zones thérapeutiques comprenant le cancer et des états impliquant un dysfonctionnement mitochondrial. (I)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)