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1. (WO2018060556) METHOD FOR DETERMINING RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASES

Pub. No.:    WO/2018/060556    International Application No.:    PCT/FI2017/050680
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Thu Sep 28 01:59:59 CEST 2017
IPC: G01N 33/53
G01N 33/68
G01N 33/573
Applicants: OY MEDIX BIOCHEMICA AB
Inventors: PUSSINEN, Pirkko
SORSA, Timo
SALOMAA, Veikko
JUHILA, Juuso
KORVUO, Armi
TIISALA, Sinikka
Title: METHOD FOR DETERMINING RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASES
Abstract:
The present invention relates to a novel method for determining risk of cardiovascular diseases comprising detecting of MMP-8 and CRP in a sample, and comparing the detected amounts with respective predetermined values of MMP-8 and CRP, wherein the detection of elevated levels of MMP-8 and CRP is indicative of presence or risk of cardiovascular event or disease. The present invention relates also to the use of detection of MMP-8 and CRP for predicting a risk for getting a cardiovascular event, for monitoring the effect of therapy on cardiovascular event or on cardiovascular disease, or for detecting the presence of a subclinical cardiovascular disease. Also, a method for constructing a risk prediction model for a presence of CVD disease or a risk of CVD events is presented.