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1. (WO2018060514) METHODS AND COMPOSITIONS COMBINING AT LEAST ONE PATTERN RECOGNITION RECEPTOR (PRR) AGONIST WITH AN ANTI-IL10 RECEPTOR ANTIBODY
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Pub. No.: WO/2018/060514 International Application No.: PCT/EP2017/074949
Publication Date: 05.04.2018 International Filing Date: 02.10.2017
IPC:
A61K 39/39 (2006.01) ,A61K 39/395 (2006.01) ,A61K 45/06 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 47/68 (2017.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
[IPC code unknown for A61K 47/68]
Applicants: GALDERMA RESEARCH & DEVELOPMENT[FR/FR]; 2400 Route des Colles, Les Templiers 06410 Biot, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE[FR/FR]; 3 rue Michel-Ange 75016 PARIS, FR
Inventors: ANJUERE, Fabienne; FR
LUCI, Carmelo; FR
HACINI-RACHINEL, Feriel; FR
VIAL, Emmanuel; FR
Agent: CABINET BECKER ET ASSOCIES; 25, rue Louis le Grand 75002 Paris, FR
Priority Data:
62/402,33430.09.2016US
Title (EN) METHODS AND COMPOSITIONS COMBINING AT LEAST ONE PATTERN RECOGNITION RECEPTOR (PRR) AGONIST WITH AN ANTI-IL10 RECEPTOR ANTIBODY
(FR) PROCÉDÉS ET COMPOSITIONS COMBINANT AU MOINS UN AGONISTE DU RÉCEPTEUR DE RECONNAISSANCE DE MOTIF (PRR) AVEC UN ANTICORPS ANTI-RÉCEPTEUR IL10
Abstract:
(EN) Methods and compositions for use for treating a precancerous lesion and/or a skin carcinoma, said composition comprising (i) at least one Pattern Recognition Receptor (PRR) agonist which potentiates IL12 secretion, and (ii) an anti-IL10 Receptor (IL10R) antibody which antagonizes IL-10-mediated protumor immunosuppression.
(FR) L'invention concerne également des procédés et des compositions destinés à être utilisés pour traiter une lésion précancéreuse et/ou un carcinome cutané, ladite composition comprenant (i) au moins un agoniste du récepteur de reconnaissance de motif (PRR) qui potentialise la sécrétion de l'IL12, et (ii) un anticorps anti-récepteur IL10 (IL10R) qui a une action antagoniste vis-à-vis de l'immunosuppression pro-tumorale médiée par IL -10.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)