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1. (WO2018060447) METHOD FOR REMOVING INHIBITORY COMPONENTS

Pub. No.:    WO/2018/060447    International Application No.:    PCT/EP2017/074812
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: G01N 33/543
G01N 33/569
Applicants: BIOPROMIC AB
Inventors: HAMASUR, Beston
IGNATOWICZ, Lech
Title: METHOD FOR REMOVING INHIBITORY COMPONENTS
Abstract:
The present invention relates to an in vitro method for detecting the presence of one or more disease- related component(s) in a diagnostic sample comprising a biological fluid selected from the group consisting of a secreted body fluid, an excreted body fluid and cerebral spinal fluid. The method comprises the steps of a) contacting said sample with a solid phase having conjugated to at least a part thereof one or more ligand(s), said ligand(s) having an affinity for and being capable of binding to one or more inhibitory component present in said sample; b) allowing said one or more inhibitory component(s) to bind to the one or more ligand(s) present on said solid phase, thereby decreasing the amount of said one or more inhibitory component(s) in said sample; and thereafter c) detecting the presence of one or more disease-related component(s) in said diagnostic sample. The one or more inhibitory component(s) are characterized as capable of binding to and interfering with the detection in step c).