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1. (WO2018060396) OMEGA 3 FATTY ACIDS AND CHOLINE AS NEUROPROTECTANT IN PATIENTS WITH NO DEMENTIA

Pub. No.:    WO/2018/060396    International Application No.:    PCT/EP2017/074731
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Sat Sep 30 01:59:59 CEST 2017
IPC: A61K 31/202
A61P 25/28
A61K 31/14
Applicants: NESTEC S.A.
Inventors: RIEKER, Claus
HUDRY-LABBE, Julie
SCHMITT, Jeroen Antonius Johannes
BOSCHAT, Corina
SILBER, Yvonne Beata
Title: OMEGA 3 FATTY ACIDS AND CHOLINE AS NEUROPROTECTANT IN PATIENTS WITH NO DEMENTIA
Abstract:
A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid and choline. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human. The composition can be administered to the individual in a daily dose that provides 5.5 mg/day to 5,500 mg/day of the choline, for example 85 mg/day to 3,500 mg/day of the choline.