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1. (WO2018060372) COMPOSITION COMPRISING AT LEAST ONE WATER-SOLUBLE PHARMACEUTICALLY ACCEPTABLE SALT OF ELAFIBRANOR HAVING IMPROVED INTESTINAL ABSORPTION

Pub. No.:    WO/2018/060372    International Application No.:    PCT/EP2017/074701
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: A61K 31/192
A61K 9/00
A61P 1/16
Applicants: NASHPHARM
Inventors: LARUELLE, Claude
BONNAFOUS, Ludovic
Title: COMPOSITION COMPRISING AT LEAST ONE WATER-SOLUBLE PHARMACEUTICALLY ACCEPTABLE SALT OF ELAFIBRANOR HAVING IMPROVED INTESTINAL ABSORPTION
Abstract:
The present invention concerns a composition comprising, as the active agent, a pharmaceutically acceptable salt of elafibranor, characterised in that the pharmaceutically acceptable salt of elafibranor is chosen from at least a salt of choline, or of ethanolamine, or of diethanolamine, or of L-lysine, or of piperazine, or of calcium or of tromethamine. The invention more particularly concerns the use of salts of elafibranor with a view to improving the stability and solubility compared with elafibranor in the basic form of same. These salts can be used in order to establish pharmaceutical formulations in various advantageous forms, such as intravenous injections or enteral formulations that have faster and less variable absorption, and therefore improved bioavailability.