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1. (WO2018060312) PTH COMPOUNDS WITH LOW PEAK-TO-TROUGH RATIOS

Pub. No.:    WO/2018/060312    International Application No.:    PCT/EP2017/074594
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: A61K 38/29
A61K 9/00
A61K 47/34
Applicants: ASCENDIS PHARMA BONE DISEASES A/S
Inventors: SPROGØE, Kennett
HOLTEN-ANDERSEN, Lars
KARPF, David Brian
Title: PTH COMPOUNDS WITH LOW PEAK-TO-TROUGH RATIOS
Abstract:
The present invention relates to a pharmaceutical composition comprising a PTH compound, wherein after subcutaneous administration the pharmacokinetic profile of the PTH compound exhibits a peak to trough ratio of less than 4 within one injection interval.