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1. (WO2018060310) DOSAGE REGIMEN FOR A CONTROLLED-RELEASE PTH COMPOUND

Pub. No.:    WO/2018/060310    International Application No.:    PCT/EP2017/074592
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: A61K 38/29
A61K 9/00
A61K 47/34
A61K 9/16
Applicants: ASCENDIS PHARMA BONE DISEASES A/S
Inventors: HOLTEN-ANDERSEN, Lars
SPROGØE, Kennett
KARPF, David Brian
Title: DOSAGE REGIMEN FOR A CONTROLLED-RELEASE PTH COMPOUND
Abstract:
The present invention relates to a pharmaceutical composition comprising at least one controlled-release PTH compound or a pharmaceutically acceptable salt, hydrate or solvate thereof, for use in the treatment, control, delay or prevention of a condition that can be treated, controlled, delayed or prevented with PTH, pharmaceutical composition comprising at least one controlled-release PTH compound or a pharmaceutically acceptable salt, hydrate or solvate thereof, for use in the treatment, control, delay or prevention of a condition that can be treated, controlled, delayed or prevented with PTH, wherein said pharmaceutical composition is administered no more frequent than once every 24 hours with a dosage of the controlled-release PTH compound that corresponds to no more than 70% of the molar equivalent dose of PTH 1-84 administered every 24 hours required to maintain serum calcium within normal levels over said 24 hour period in humans.