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1. (WO2018060300) BRIDGED PIPERIDINE DERIVATIVES

Pub. No.:    WO/2018/060300    International Application No.:    PCT/EP2017/074575
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 29 01:59:59 CEST 2017
IPC: C07D 519/00
A61K 31/4196
A61P 25/28
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: BARTELS, Bjoern
JAKOB-ROETNE, Roland
LIMBERG, Anja
NEIDHART, Werner
RATNI, Hasane
REUTLINGER, Michael
SARIE, Jérôme Charles
VASTAKAITE, Greta
Title: BRIDGED PIPERIDINE DERIVATIVES
Abstract:
The present invention relates to a compound of formula (I), wherein R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy or lower alkoxy substituted by halogen; R may be the same or different, if n = 2 or 3; n is 1, 2 or 3; m is 1, 2 or 3; Ar is a five or six membered heteroaryl group, selected from (II), (III), (IV) or (V) wherein R 2 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen or lower alkoxy; R 3 is hydrogen or halogen; -() m - is –(CH 2 )m- or to pharmaceutically active acid addition salts thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.