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1. (WO2018059914) METHOD FOR PRODUCING THE CRYSTALLINE FORM OF MODIFICATION A OF CALCOBUTROL
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/059914 International Application No.: PCT/EP2017/072683
Publication Date: 05.04.2018 International Filing Date: 11.09.2017
IPC:
C07D 257/02 (2006.01) ,A61K 49/10 (2006.01)
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT[DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors: PLATZEK, Johannes; DE
TRENTMANN, Wilhelm; DE
Agent: BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein NRW, DE
Priority Data:
16190812.427.09.2016EP
Title (EN) METHOD FOR PRODUCING THE CRYSTALLINE FORM OF MODIFICATION A OF CALCOBUTROL
(FR) PROCÉDÉ DE PRODUCTION DE LA FORME CRISTALLINE DE MODIFICATION A DE CALCOBUTROL
(DE) METHOD FOR PRODUCING THE CRYSTALLINE FORM OF MODIFICATION A OF CALCOBUTROL
Abstract: front page image
(EN) A method is described for production of a high purity compound of the formula (I) in crystalline form of the modification A. In this, starting from high purity gadobutrol, the gadolinium is removed by decomplexation with oxalic acid, and then with a calcium salt the calcium complex is produced in high purity. During the crystallization, a water equivalent of 9-11 weight % is set. The crystalline form of the modification A of the compound of the formula (I) is used in the production of Gadovist.
(FR) L'invention concerne un procédé de production d'un composé de grande pureté de formule (I) sous la forme cristalline de la modification A. À partir d'oxyde de gadobutrol de haute pureté, le gadolinium est éliminé par décomplexation avec de l'acide oxalique, et ensuite avec un sel de calcium, le complexe de calcium est produit avec une pureté élevée. Pendant la cristallisation, un équivalent d'eau de 9-11 % en poids est fixé. La forme cristalline de la modification A du composé de formule (I) est utilisée dans la production de Gadovist.
(DE) BHC 163074 Foreign Filing - 24 - Abstract A method is described for production of a high purity compound of the formula (I) (+,-) OH OH N N O O – NO OH NO O – HO Ca 2+ (I)5 in crystalline form of the modification A. In this, starting from high purity gadobutrol, the gadolinium is removed by decomplexation with oxalic acid, and then with a calcium salt the calcium complex is produced in high purity. During the crystallization, a water equivalent of 9 - 11 weight % is set. The crystalline form of the modification A of the compound of the formula10 (I) is used in the production of Gadovist.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)