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1. (WO2018059549) IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/059549 International Application No.: PCT/CN2017/104422
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
C07D 401/04 (2006.01) ,C07D 209/14 (2006.01) ,A61K 31/33 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
14
Radicals substituted by nitrogen atoms, not forming part of a nitro radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: MOTZ, Gregory[US/US]; US (US)
MAVRAKIAS, Konstantinos John[US/US]; US (US)
LIU, Jinbiao[CN/CN]; CN (US)
LIU, Lei[CN/CN]; CN (US)
ZHENG, Qiangang[CN/CN]; CN (US)
XUN, Guoliang[CN/CN]; CN (US)
XIAO, Qitao[CN/CN]; CN (US)
NOVARTIS AG[CH/CH]; Lichtstrasse 35 4056 Basel, CH
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA[US/US]; Suite 200, 3160 Chestnut Street Philadelphia, Pennsylvania 19104, US
Inventors: MOTZ, Gregory; US
MAVRAKIAS, Konstantinos John; US
LIU, Jinbiao; CN
LIU, Lei; CN
ZHENG, Qiangang; CN
XUN, Guoliang; CN
XIAO, Qitao; CN
Agent: ZHONGZI LAW OFFICE; 7F, New Era Building 26 Pinganli Xidajie, Xicheng District Beijing 100034, CN
Priority Data:
PCT/CN2016/10121330.09.2016CN
Title (EN) IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY
(FR) THÉRAPIES À BASE DE CELLULES EFFECTRICES IMMUNITAIRES À EFFICACITÉ AMÉLIORÉE
Abstract:
(EN) Provided herein is the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.
(FR) L'invention concerne l'utilisation d'inhibiteurs de LSD1 en rapport avec l'utilisation et la fabrication de cellules effectrices immunitaires (par exemple, lymphocytes T, cellules NK), par exemple, modifiées pour exprimer un récepteur d'antigène chimérique (CAR), pour traiter un sujet atteint d'une maladie, par exemple une maladie associée à l'expression d'un antigène tumoral.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)