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1. (WO2018059533) P38Α MAPK KINASE INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/059533    International Application No.:    PCT/CN2017/104247
Publication Date: 05.04.2018 International Filing Date: 29.09.2017
IPC:
C07D 231/38 (2006.01), A61K 31/415 (2006.01), A61P 29/00 (2006.01)
Applicants: MEDSHINE DISCOVERY INC. [CN/CN]; Room 218, No.9 Gaoxin Road Gaoxin Development District Nanjing, Jiangsu 210032 (CN)
Inventors: WU, Lingyun; (CN).
ZHANG, Li; (CN).
ZHAO, Lele; (CN).
LI, Jian; (CN).
CHEN, Shuhui; (CN)
Agent: SHANGHAI BESHINING LAW OFFICE; 21st Floor, SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032 (CN)
Priority Data:
201610867718.X 29.09.2016 CN
Title (EN) P38Α MAPK KINASE INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF
(FR) INHIBITEUR DE LA P38Α MAPK KINASE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) p38αMAPK激酶抑制剂及其制备方法和应用
Abstract: front page image
(EN)Disclosed is a class of pyrazole compounds of formula (I) having a p38α inhibitory effect, and included are uses of the compounds in the field of p38α-related diseases, such as various inflammatory diseases and immunological abnormalities. In addition, also disclosed are the synthesis and preparation method for the series of pyrazole compounds.
(FR)L'invention concerne une classe de composés de pyrazole de formule (I) ayant un effet inhibiteur de p38α, et des utilisations des composés dans le domaine des maladies associées à p38α, telles que diverses maladies inflammatoires et des anomalies immunologiques. De plus, l'invention concerne également la synthèse et le procédé de préparation de la série de composés pyrazole.
(ZH)公开了一类具有p38α的抑制作用的吡唑类化合物式(I),并包含这些化合物在p38α相关疾病领域的应用,比如各种炎症以及免疫异常等疾病,此外还公开了该系列吡唑类化合物的合成及制备方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)