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1. (WO2018059502) HETERODIMERIC IMMUNOGLOBULIN CONSTRUCTS AND PREPARATION METHODS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/059502    International Application No.:    PCT/CN2017/104044
Publication Date: 05.04.2018 International Filing Date: 28.09.2017
IPC:
C07K 16/00 (2006.01), A61K 39/395 (2006.01), C12N 15/13 (2006.01), A61P 37/02 (2006.01), A61P 35/00 (2006.01)
Applicants: BEIJING HANMI PHARMACEUTICAL CO., LTD. [CN/CN]; No.10 Tianzhu West Road Tianzhu Airport Industrial Zone A Shunyi District, Beijing 101312 (CN)
Inventors: LIU, Jiawang; (CN).
SONG, Nanmeng; (CN).
YANG, Dongge; (CN).
YANG, Yaping; (CN).
KIM, Maengsup; (CN)
Agent: BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD.; 1802, 1803, 1805 Tower B, Grand Place No 5 Huizhong Road, Chaoyang District Beijing 100101 (CN)
Priority Data:
201610863814.7 29.09.2016 CN
Title (EN) HETERODIMERIC IMMUNOGLOBULIN CONSTRUCTS AND PREPARATION METHODS THEREOF
(FR) CONSTRUCTIONS D'IMMUNOGLOBULINES HÉTÉRODIMÉRIQUES ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract: front page image
(EN)Provided is a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target molecules and are more potent in the treatment of complex diseases.
(FR)L'invention concerne un procédé de production de constructions d'immunoglobulines hétérodimériques stables et hautement spécifiques, par exemple des anticorps bispécifiques, préservant les propriétés souhaitables des IgG natives et sans appariement indésirable chaîne légère-chaîne lourde, qui peuvent se lier simultanément à deux molécules cibles et sont plus puissantes dans le traitement de maladies complexes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)