Processing

Please wait...

Settings

Settings

Goto Application

1. WO2018059455 - 1-[(PYRIDIN-3-YL-SULFONYL)-1H-PYRROL-3-YL] METHANAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Publication Number WO/2018/059455
Publication Date 05.04.2018
International Application No. PCT/CN2017/103744
International Filing Date 27.09.2017
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 1/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
CPC
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • 江苏吉贝尔药业股份有限公司 JIANGSU JIBEIER PHARMACEUTICAL CO. LTD. [CN]/[CN]
  • 镇江圣安医药有限公司 ZHENJIANG SAN AN PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 耿仲毅 GENG, Zhongyi
  • 陈兴海 CHEN, Xinghai
Agents
  • 北京林达刘知识产权代理事务所(普通合伙) LINDA LIU & PARTNERS
Priority Data
201610870802.729.09.2016CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) 1-[(PYRIDIN-3-YL-SULFONYL)-1H-PYRROL-3-YL] METHANAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
(FR) DÉRIVÉ DE 1- [(PYRIDIN-3-YL-SULFONYL) -1 H-PYRROL-3-YL] MÉTHANAMINE, COMPOSITION PHARMACEUTIQUE ET SON UTILISATION
(ZH) 1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物及其药物组合物和用途
Abstract
(EN) Provided in the present invention are a 1-[(pyridin-3-yl-sulfonyl)-1h-pyrrol-3-yl] methanamine derivative having the structure shown below in formula (I) and a pharmaceutical composition and use thereof. The 1-[(pyridin-3-yl-sulfonyl)-1h-pyrrol-3-yl] methanamine derivative provided in the present invention has good gastric acid secretion inhibitory activities and excellent pharmacodynamic properties, while having relatively low toxicity.
(FR) La présente invention concerne un dérivé de 1- [(pyridin-3-yl-sulfonyle) -1 h-pyrrol-3-yl] méthanamine ayant la structure représentée ci-dessous dans la formule (I) et une composition pharmaceutique et l'utilisation de celui-ci. Le dérivé de 1- [(pyridin-3-yl-sulfonyle) -1 h-pyrrol-3-yl] méthanamine selon la présente invention présente de bonnes activités inhibitrices de la sécrétion d'acide gastrique et d'excellentes propriétés pharmacodynamiques, tout en ayant une toxicité relativement faible.
(ZH) 本发明提供一种具备如下式(I)所示结构的1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物及其药物组合物和用途。本发明提供的1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物,具有良好的胃酸分泌抑制活性和优异的药效学性能,以及较低的毒性。
Latest bibliographic data on file with the International Bureau