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1. (WO2018059455) 1-[(PYRIDIN-3-YL-SULFONYL)-1H-PYRROL-3-YL] METHANAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
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Pub. No.: WO/2018/059455 International Application No.: PCT/CN2017/103744
Publication Date: 05.04.2018 International Filing Date: 27.09.2017
IPC:
C07D 401/12 (2006.01) ,A61K 31/4439 (2006.01) ,A61P 1/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
04
for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants:
江苏吉贝尔药业股份有限公司 JIANGSU JIBEIER PHARMACEUTICAL CO. LTD. [CN/CN]; 中国江苏省镇江市 高新技术开发园区南纬二路18号 No. 18, Nanwei 2nd Road High-Tech Industrial Development Zone Zhenjiang, Jiangsu 212009, CN
镇江圣安医药有限公司 ZHENJIANG SAN AN PHARMACEUTICAL CO., LTD. [CN/CN]; 中国江苏省镇江市 润州区润兴路金泰大厦北单元4楼407室 Suite 407, North Wing, Jintai Building Runxing Road, Runzhou District Zhenjiang, Jiangsu 212004, CN
Inventors:
耿仲毅 GENG, Zhongyi; CN
陈兴海 CHEN, Xinghai; CN
Agent:
北京林达刘知识产权代理事务所(普通合伙) LINDA LIU & PARTNERS; 中国北京市 东城区北三环东路36号北京环球贸易中心C座16层 F16, Tower C, Beijing Global Trade Center 36 North Third Ring East Road, Dongcheng District Beijing 100013, CN
Priority Data:
201610870802.729.09.2016CN
Title (EN) 1-[(PYRIDIN-3-YL-SULFONYL)-1H-PYRROL-3-YL] METHANAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
(FR) DÉRIVÉ DE 1- [(PYRIDIN-3-YL-SULFONYL) -1 H-PYRROL-3-YL] MÉTHANAMINE, COMPOSITION PHARMACEUTIQUE ET SON UTILISATION
(ZH) 1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物及其药物组合物和用途
Abstract:
(EN) Provided in the present invention are a 1-[(pyridin-3-yl-sulfonyl)-1h-pyrrol-3-yl] methanamine derivative having the structure shown below in formula (I) and a pharmaceutical composition and use thereof. The 1-[(pyridin-3-yl-sulfonyl)-1h-pyrrol-3-yl] methanamine derivative provided in the present invention has good gastric acid secretion inhibitory activities and excellent pharmacodynamic properties, while having relatively low toxicity.
(FR) La présente invention concerne un dérivé de 1- [(pyridin-3-yl-sulfonyle) -1 h-pyrrol-3-yl] méthanamine ayant la structure représentée ci-dessous dans la formule (I) et une composition pharmaceutique et l'utilisation de celui-ci. Le dérivé de 1- [(pyridin-3-yl-sulfonyle) -1 h-pyrrol-3-yl] méthanamine selon la présente invention présente de bonnes activités inhibitrices de la sécrétion d'acide gastrique et d'excellentes propriétés pharmacodynamiques, tout en ayant une toxicité relativement faible.
(ZH) 本发明提供一种具备如下式(I)所示结构的1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物及其药物组合物和用途。本发明提供的1-[(吡啶-3-基-磺酰基)-1H-吡咯-3-基]甲胺衍生物,具有良好的胃酸分泌抑制活性和优异的药效学性能,以及较低的毒性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)