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1. (WO2018059437) TREATMENT CANCERS USING COMBINATION COMPRISING PARP INHIBITORS

Pub. No.:    WO/2018/059437    International Application No.:    PCT/CN2017/103660
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Thu Sep 28 01:59:59 CEST 2017
IPC: A61P 35/00
C07D 487/06
C07D 471/16
C07D 471/22
C07K 16/28
A61K 31/551
Applicants: BEIGENE, LTD.
WANG, Lai
Inventors: WANG, Lai
TANG, Zhiyu
LUO, Lusong
WEI, Min
LI, Kang
SONG, Jing
ZHANG, Tong
WANG, Hexiang
REN, Bo
ZHOU, Changyou
Title: TREATMENT CANCERS USING COMBINATION COMPRISING PARP INHIBITORS
Abstract:
Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R) -2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R) -2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H) -one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.