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1. (WO2018059429) NON-SOLVATED CRYSTAL, PREPARATION METHOD AND APPLICATION THEREOF

Pub. No.:    WO/2018/059429    International Application No.:    PCT/CN2017/103620
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Thu Sep 28 01:59:59 CEST 2017
IPC: C07D 215/233
A61K 31/47
A61P 29/00
A61P 37/06
A61P 35/00
A61P 25/00
A61P 25/28
A61P 9/00
A61P 3/00
A61P 37/08
A61P 11/06
A61P 35/02
Applicants: SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.
深圳微芯生物科技有限责任公司
Inventors: LU, Xianping
鲁先平
LI, Zhibin
李志斌
Title: NON-SOLVATED CRYSTAL, PREPARATION METHOD AND APPLICATION THEREOF
Abstract:
The invention relates to non-solvated crystals A, B and C of N-(2-aminophenyl)-6-(7-methoxyquinoline-4-oxy)-1-naphthamide and preparation methods thereof. The invention also relates to pharmaceutical compositions containing the crystals, and a use of the crystals in preparation of a medicament for the treatment of a disease associated with abnormal protein kinase activity or abnormal histone deacetylase activity.