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1. (WO2018059427) METHOD FOR PREPARING PHENYLALANINE COMPOUND
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/059427 International Application No.: PCT/CN2017/103618
Publication Date: 05.04.2018 International Filing Date: 27.09.2017
IPC:
C07D 209/86 (2006.01) ,C07C 229/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
82
Carbazoles; Hydrogenated carbazoles
86
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
229
Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02
having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
34
the carbon skeleton containing six-membered aromatic rings
36
with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Applicants: SHENZHEN CHIPSCREEN BIOSCIENCES, LTD.[CN/CN]; 2-601~606 BIO-Incubator, Gaoxin C, 1st Ave., Hi-Tech Industrial Park Nanshan District Shenzhen, Guangdong 518057, CN
Inventors: LU, Xianping; CN
LI, Zhibin; CN
WANG, Xianghui; CN
Agent: SHENPAT INTELLECTUAL PROPERTY AGENCY; Room 1521 West Block, Guomao Building Shenzhen, Guangdong 518014, CN
Priority Data:
201610855107.327.09.2016CN
Title (EN) METHOD FOR PREPARING PHENYLALANINE COMPOUND
(FR) PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ PHÉNYLALANINE
(ZH) 一种苯丙氨酸类化合物的制备方法
Abstract:
(EN) Disclosed is a method for preparing 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)propanoic acid. In the method 9-carbazole ethanol mesylate and methyl 2-[2-(4-fluorobenzoyl)phenyl)amino]-3-(4-hydroxyphenyl)propionate are used as starting materials, and subjected to condensation, hydrolysis and acidification to obtain the target compound. The preparation method of the present invention is suitable for industrial production, and the target compound has a high purity.
(FR) L'invention concerne un procédé de préparation de l'acide 2- (2- (4-fluorobenzoyl) phénylamino)-3-(4- (2- (9H-carbazol-9-yl) éthoxy) phényl) propanoïque. Dans le procédé, du mésylate d'éthanol de 9-carbazole et du 2- [2- (4-fluorobenzoyl) phényl) amino]-3-(4-hydroxyphényl) méthyl-2-[2- (4-fluorobenzoyl) phényl) amino]-3-(4-hydroxyphényl)) propionate sont utilisés en tant que matières premières, et sont soumis à une condensation, une hydrolyse et une acidification pour obtenir le composé cible. Le procédé de préparation de la présente invention est approprié pour une production industrielle, et le composé cible a une pureté élevée.
(ZH) 本发明公开了2-(2-(4-氟苯甲酰基)苯基氨基)-3-(4-(2-(9H-咔唑-9-基)乙氧基)苯基)丙酸的制备方法,该方法以9-咔唑乙醇甲磺酸酯和2-[(2-(4-氟苯甲酰基)苯基)氨基]-3-(4-羟基苯基)丙酸甲酯为起始原料,经缩合、水解、酸化得到目标化合物。本发明所述制备方法适合工业化生产,所得目标化合物纯度高。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)