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1. (WO2018059372) METHOD OF USE OF DITERPENOID DERIVATIVES AS ANTICANCER AGENTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/059372 International Application No.: PCT/CN2017/103320
Publication Date: 05.04.2018 International Filing Date: 26.09.2017
IPC:
C07D 319/08 (2006.01) ,C07D 493/08 (2006.01) ,C07C 69/12 (2006.01) ,A61K 31/357 (2006.01) ,A61K 31/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
319
Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
04
1,3-Dioxanes; Hydrogenated 1,3-dioxanes
08
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
02
Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
12
Acetic acid esters
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
Applicants: HONG KONG BAPTIST UNIVERSITY[CN/CN]; Kowloon Tong Kowloon, Hong Kong, CN
Inventors: ZHANG, Hongjie; CN
WONG, Man Shing Ricky; CN
GUO, Lei; CN
TSANG, Siu Wai; CN
LIU, Kanglun; CN
ZHANG, Tongxin; CN
Agent: DHC IP ATTORNEYS; Suite 2201, Modern International Commercial Building, Cross of Fuhua Road and Jintian Road Futian District Shenzhen, Guangdong 518048, CN
Priority Data:
15/277,70027.09.2016US
15/710,84221.09.2017US
Title (EN) METHOD OF USE OF DITERPENOID DERIVATIVES AS ANTICANCER AGENTS
(FR) PROCÉDÉ D'UTILISATION DE DÉRIVÉS DE DITERPÉNOÏDES EN TANT QU'AGENTS ANTICANCÉREUX
Abstract:
(EN) The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.
(FR) La présente invention concerne un groupe de dérivés synthétisés sur la base de l'ent-kaurane diterpénoïde flexicaulin A et les procédés de synthèse de tels dérivés de diterpénoïdes. En particulier, les entités chimiques de tels composés de diterpène synthétiques dans la fabrication d'un médicament sont destinées au traitement de tumeurs ou de cancers.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)