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|1. (WO2018059331) POLYAMIDE COMPOUND AND USE THEREOF|
|Applicants:||SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
|Title:||POLYAMIDE COMPOUND AND USE THEREOF|
The present invention relates to a polyamide compound and a use thereof; specifically, the present invention relates to a type of polyamide compound (which preferably contains one or more amide bonds formed by the condensation of same or different L-amino acids or D-amino acids), or stereoisomers thereof, polymorphs thereof, solvates thereof, or metabolites thereof, prodrugs thereof or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with a κ-opioid receptor. The polyamide compound of the present invention has excellent κ-opioid receptor agonistic activities and hydrophilic ability, thus having a lesser ability of penetrating the blood-brain barrier and a lowered capacity for entering the brain. The compound of the present invention has higher selectivity for a κ-opioid receptor, lowered addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects, good patient compliance, and/or a lesser propensity for developing tolerance, among other excellent medicinal properties).