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1. (WO2018059257) CO-CRYSTAL AND/OR EUTECTIC CRYSTAL OF KOJIC ACID, COMPOSITIONS COMPRISING THE SAME, PROCESS OF PRODUCING THE SAME, AND USES THEREOF

Pub. No.:    WO/2018/059257    International Application No.:    PCT/CN2017/102018
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Tue Sep 19 01:59:59 CEST 2017
IPC: A61K 31/045
A61K 31/122
A61K 31/047
Applicants: TSAI, Guo-Chuan Emil
Inventors: TSAI, Guo-Chuan Emil
WANG, Ching-Cheng
HSIEH, Tien-Lan
Title: CO-CRYSTAL AND/OR EUTECTIC CRYSTAL OF KOJIC ACID, COMPOSITIONS COMPRISING THE SAME, PROCESS OF PRODUCING THE SAME, AND USES THEREOF
Abstract:
Novel co-crystal and eutectic crystal of kojic acid and a co-former that are excellent in physical properties are provided. In one aspect, novel co-crystals of kojic acid and a co-former that is maltol or ethyl maltol are provided. In another aspect, novel crystal of a eutectic mixture of kojic acid and a co-former that is selected from the group consisting of, maltol, ethyl maltol, methyl paraben and propyl gallate are provided. Methods for producing the novel co-crystal or eutectic crystal are also described. The novel co-crystals and eutectic crystals may be included in a pharmaceutical composition, a health food product or a medical food product for the treatment and/or prophylaxis of a neuropsychiatric disorder.