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1. (WO2018058874) GEL FIBER COMPOSITE SCAFFOLD MATERIAL FORMED THROUGH ONE STEP AND PREPARATION METHOD AND USE THEREOF
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Pub. No.: WO/2018/058874 International Application No.: PCT/CN2017/072608
Publication Date: 05.04.2018 International Filing Date: 25.01.2017
IPC:
A61L 27/26 (2006.01) ,A61L 27/20 (2006.01) ,C12N 5/00 (2006.01) ,D04H 1/728 (2012.01) ,D06M 13/322 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
26
Mixtures of macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
20
Polysaccharides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
D TEXTILES; PAPER
04
BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
H
MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING
1
Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
70
characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
72
the fibres being randomly arranged
728
by electro-spinning
D TEXTILES; PAPER
06
TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
M
TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D0664
13
Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
322
with compounds containing nitrogen
Applicants:
国家纳米科学中心 NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY [CN/CN]; 中国北京市 海淀区中关村北一条11号 No. 11, Beiyitiao Alley, Zhongguancun, Haidian District, Beijing 100190, CN
Inventors:
韩鑫晓 HAN, Xinxiao; CN
韩东 HAN, Dong; CN
Agent:
北京路浩知识产权代理有限公司 CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED; 中国北京市 海淀区丹棱街3号中国电子大厦B座18层 18th Floor, Tower B, CEC Plaza No. 3 Dan Ling Street,Haidian District Beijing 100080, CN
Priority Data:
201610866896.029.09.2016CN
Title (EN) GEL FIBER COMPOSITE SCAFFOLD MATERIAL FORMED THROUGH ONE STEP AND PREPARATION METHOD AND USE THEREOF
(FR) MATÉRIAU D'ÉCHAFAUDAGE COMPOSITE À BASE DE FIBRES DE GEL FORMÉ EN UNE ÉTAPE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一次成型的凝胶纤维复合支架材料及其制备方法与应用
Abstract:
(EN) Provided are a gel fiber composite scaffold material formed through one step and a preparation method and a use thereof. The preparation method of the composite scaffold material comprises steps as follows: preparing an electrospun film through a high-voltage electrostatic method; and soaking the electrospun film into a phase separation solution to obtain the gel fiber composite scaffold material. The obtained composite scaffold material is an extracellular matrix simulated composite material and can be modified by adding multiple natural biomaterials, so that the composite material is closer to an extracellular matrix in terms of components.
(FR) L'invention concerne un matériau d'échafaudage composite à base de fibres de gel formé en une étape ainsi qu'un procédé de préparation et une utilisation associés. Le procédé de préparation du matériau d'échafaudage composite comprend les étapes suivantes : la préparation d'un film électrofilé par l'intermédiaire d'un procédé électrostatique à haute tension; et le trempage du film électrofilé dans une solution de séparation de phases pour obtenir le matériau d'échafaudage composite à base de fibres de gel. Le matériau d'échafaudage composite obtenu est un matériau composite simulant la matrice extracellulaire et peut être modifié par l'ajout de multiples biomatériaux naturels, de sorte que le matériau composite soit plus proche d'une matrice extracellulaire en termes de constituants.
(ZH) 一种一次成型的凝胶纤维复合支架材料及其制备方法与应用。该复合支架材料的制备方法包括通过高压静电方法制备电纺丝薄膜;然后浸泡于相分离溶液中制得。制得的复合支架材料是一种仿细胞外基质复合材料,还可添加多种天然生物材料进行改造,使之成分上更接近细胞外基质。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)