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1. (WO2018058723) A METHOD FOR ENZYMATIC SYNTHESIS OF SIALIC ACID ANALOGUE AND APPLICATION THEREOF
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Pub. No.:    WO/2018/058723    International Application No.:    PCT/CN2016/103803
Publication Date: 05.04.2018 International Filing Date: 28.10.2016
IPC:
C12P 19/26 (2006.01), C07H 5/06 (2006.01)
Applicants: NANJING AGRICULTURAL UNIVERSITY [CN/CN]; No.1 Weigang, Xuanwu Nanjing, Jiangsu 210095 (CN)
Inventors: VOGLMEIR, Josef; (CN).
LIU, Li; (CN).
LABORDA, Pedro; (CN).
WANG, Suyan; (CN)
Agent: NANJING TIANHUA PATENT AGENT CO., LTD.; Floor 23, Block A1, World Trade Center Building No. 67 Shanxi Road, Gulou Nanjing, Jiangsu 210009 (CN)
Priority Data:
201610864319.8 28.09.2016 CN
Title (EN) A METHOD FOR ENZYMATIC SYNTHESIS OF SIALIC ACID ANALOGUE AND APPLICATION THEREOF
(FR) PROCÉDÉ DE SYNTHÈSE ENZYMATIQUE D'ANALOGUE D'ACIDE SIALIQUE ET SON APPLICATION
(ZH) 一种酶法合成唾液酸类似物的方法及其应用
Abstract: front page image
(EN)Provided are a method for enzymatic synthesis of a sialic acid analogue: with sialic acid aldolase as a catalyst, subjecting a substrate containing an aldehyde group to a condensation reaction with a substrate containing a carbonyl group, to obtain a sialic acid analogue. The synthesized sialic acid analogue can be used as a potential neuraminidase inhibitor, or as a template of the potential neuraminidase inhibitor.
(FR)L'invention concerne un procédé de synthèse enzymatique d'un analogue d'acide sialique : au moyen d'acide sialique aldolase comme catalyseur, soumettre un substrat contenant un groupe aldéhyde à une réaction de condensation avec un substrat contenant un groupe carbonyle, pour obtenir un analogue d'acide sialique. L'analogue d'acide sialique synthétisé peut être utilisé en tant qu'inhibiteur de la neuraminidase potentiel, ou en tant que modèle de l'inhibiteur de la neuraminidase potentiel.
(ZH)提供了一种酶法合成唾液酸类似物的方法:用唾液酸醛缩酶催化含有醛基的底物和含有羰基的底物发生缩合反应,得到唾液酸类似物。合成的唾液酸类似物可以作为潜在的神经氨酸酶抑制剂或作为潜在的神经氨酸酶抑制剂的模板。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)