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1. (WO2018058431) CHIMERIC ANTIGEN RECEPTOR MOLECULE AND USE THEREOF

Pub. No.:    WO/2018/058431    International Application No.:    PCT/CN2016/100796
Publication Date: Fri Apr 06 01:59:59 CEST 2018 International Filing Date: Fri Sep 30 01:59:59 CEST 2016
IPC: C07K 19/00
C12N 15/62
C12N 15/867
C12N 5/10
Applicants: LI, Huashun
李华顺
Inventors: LI, Huashun
李华顺
HAN, Kunkun
韩昆昆
XUE, Yanan
薛亚男
WANG, Baolei
王保垒
REN, Baoyong
任宝永
Title: CHIMERIC ANTIGEN RECEPTOR MOLECULE AND USE THEREOF
Abstract:
Provided are a chimeric antigen receptor molecule and the use thereof. The chimeric antigen receptor molecule comprises a peptide fragment in an extracellular region, a peptide fragment in a transmembrane region and a peptide fragment in an intracellular domain in successive tandem. The peptide fragment in the extracellular region is an HAC peptide fragment, and the sequence thereof is as shown in SEQ ID NO: 1. Also provided are a nucleotide, a recombinant vector and a recombinant cell using the chimeric antigen receptor molecule.