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1. (WO2018058026) MITOCHONDRIAL EPIGENETIC REPROGRAMMING AND TRANSPLANT
PCT Biblio. Data
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Pub. No.:
WO/2018/058026
International Application No.:
PCT/US2017/053224
Publication Date:
29.03.2018
International Filing Date:
25.09.2017
IPC:
A61K 35/545
(2015.01),
A61K 35/12
(2015.01)
[IPC code unknown for A61K 35/545]
A
HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
Applicants:
BOSTON SCIENTIFIC SCIMED, INC.
[US/US]; One Scimed Place MAPLE GROVE, Minnesota 55311 (US)
Inventors:
STOLEN, Craig
; (US).
SHUROS, Allan Charles
; (US)
Agent:
DEFFNER, Mark E.
; (US).
DEVRIES SMITH, Katherine M.
; (US)
Priority Data:
62/399,566
26.09.2016
US
Title
(EN)
MITOCHONDRIAL EPIGENETIC REPROGRAMMING AND TRANSPLANT
(FR)
REPROGRAMMATION ÉPIGÉNÉTIQUE MITOCHONDRIALE ET TRANSPLANTATION
Abstract:
(EN)
Embodiments herein include methods for enhancing post-ischemic functional recovery through administration of mitochondria and related devices and methods. In an embodiment, a method for enhancing post-ischemic functional recovery is included. The method can include harvesting somatic cells from a patient or a donor, converting the somatic cells into induced pluripotent stem cells, extracting mitochondria from the induced pluripotent stem cells, and transplanting the mitochondria into the patient. Other embodiments are also included herein.
(FR)
Des modes de réalisation de l'invention comprennent des procédés d'amélioration de la récupération fonctionnelle post-ischémique par l'administration de mitochondries et de dispositifs et de procédés associés. Dans un mode de réalisation, l'invention concerne un procédé d'amélioration de la récupération fonctionnelle post-ischémique. Le procédé peut comprendre la récolte de cellules somatiques provenant d'un patient ou d'un donneur, la conversion des cellules somatiques en cellules souches pluripotentes induites, l’extraction des mitochondries des cellules souches pluripotentes induites, et la transplantation (greffe) des mitochondries dans le patient. La présente invention concerne également d'autres modes de réalisation.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)