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1. (WO2018057946) TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUBSTITUTIONS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/057946 International Application No.: PCT/US2017/053041
Publication Date: 29.03.2018 International Filing Date: 22.09.2017
IPC:
A61K 48/00 (2006.01) ,C12P 19/34 (2006.01)
Applicants: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY[US/US]; 801 North Rutledge Street Springfield, IL 62974, US
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY[CA/CA]; 845 Sherbrooke Street West Montreal, H3A 0G4, CA
Inventors: GAGNON, Keith; US
DAMHA, Masad; CA
MALEK-ADAMIAN, Elise; CA
HABIBIAN, Maryam; CA
O'REILLY, Daniel, Timothy; CA
KARTJE, Zachary; US
Agent: HIBLER, David, W.; US
BAUMEISTER, Mary; US
CUMMINGS, Scott; US
BHATTARAJ, Roshan, K.; US
BOCK, Joel, N.; US
Priority Data:
62/398,77523.09.2016US
Title (EN) TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUBSTITUTIONS
(FR) RÉGLAGE DE L'ACTIVITÉ DE CRISPR/CAS9 À L'AIDE DE SUBSTITUTIONS DE NUCLÉOTIDES CHIMIQUEMENT MODIFIÉS
Abstract:
(EN) The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
(FR) La présente invention concerne des compositions de ribonucléoprotéines de CRISPR/Cas9 comprenant des constituants d'ARN CRISPR (ARNcr) chimiquement modifiés et des constituants d'ARN CRISPR trans-activateur (ARNtracr). L'invention concerne également des procédés d'utilisation des compositions de ribonucléoprotéines de CRISPR/Cas9.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)