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1. (WO2018057943) MODULATING RESPONSES TO CHECKPOINT INHIBITOR THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/057943    International Application No.:    PCT/US2017/053037
Publication Date: 29.03.2018 International Filing Date: 22.09.2017
IPC:
A61K 38/20 (2006.01), A61N 1/32 (2006.01), C12N 15/09 (2006.01)
Applicants: ONCOSEC MEDICAL INCORPORATED [US/US]; 5820 Nancy Ridge Drive San Diego, CA 92121 (US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, CA 94607 (US)
Inventors: PIERCE, Robert, H.; (US).
DAUD, Adil; (US)
Agent: MOHAN-PETERSON, Sheela; (US)
Priority Data:
62/399,172 23.09.2016 US
Title (EN) MODULATING RESPONSES TO CHECKPOINT INHIBITOR THERAPY
(FR) MODULATION DE RÉPONSES À UNE THÉRAPIE PAR INHIBITEUR DE POINT DE CONTRÔLE
Abstract: front page image
(EN)The present invention provides for a dosing schedule for the intratumoral delivery of an immunostimulatory cytokine in combination with systemic delivery of a checkpoint inhibitor. In particular, it provides delivery of a plasmid encoding the immunostimulatory cytokine, e.g., IL-12, using intratumoral electroporation, and the systemic delivery of a PD-1 antagonist.
(FR)L'invention concerne un programme de dosage pour l'administration intratumorale d'une cytokine immunostimulatrice en combinaison avec l'administration systémique d'un inhibiteur de point de contrôle. En particulier, l'invention concerne l'administration par électroporation intratumorale d'un plasmide codant la cytokine immunostimulatrice, par exemple IL-12, et l'administration systémique d'un antagoniste de PD-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)