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1. (WO2018057808) BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/057808    International Application No.:    PCT/US2017/052817
Publication Date: 29.03.2018 International Filing Date: 21.09.2017
IPC:
C07D 413/14 (2006.01), A61K 31/4184 (2006.01), A61K 31/4196 (2006.01), A61K 31/4709 (2006.01), A61K 31/5375 (2006.01), C07D 413/04 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), C07D 405/14 (2006.01), A61K 31/341 (2006.01), A61K 31/4025 (2006.01), A61K 31/4155 (2006.01), A61K 31/4178 (2006.01), A61K 31/4245 (2006.01), A61K 31/427 (2006.01), A61K 31/433 (2006.01), A61K 31/444 (2006.01), A61K 31/497 (2006.01), A61K 31/501 (2006.01), A61K 31/506 (2006.01), C07D 409/14 (2006.01), C07D 417/14 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, CA 94404 (US)
Inventors: CHANDRASEKHAR, Jayaraman; (US).
CODELLI, Julian, Andrew; (US).
NADUTHAMBI, Devan; (US).
PATEL, Leena; (US).
PERREAULT, Stephane; (US).
PHILLIPS, Gary; (US).
SEDILLO, Kassandra, F.; (US).
TREIBERG, Jennifer, Anne; (US).
VAN VELDHUIZEN, Joshua; (US).
WATKINS, William, J.; (US)
Agent: REANEY, Shannon; (US).
CHOI, Lydia; (US).
CAPPS, Kevin, J.; (US).
BOSS, Brandon; (US).
DAMMANN, Yu-ming; (US)
Priority Data:
62/398,744 23.09.2016 US
Title (EN) BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
(FR) DÉRIVÉS DE BENZIMIDAZOLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHATIDYLINOSITOL 3-KINASE
Abstract: front page image
(EN)The present application provides the compounds of formula I or IA or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, m, n, R1, R2, R3, R4, R5, R6 and R7are as described herein. The compounds of formula I or IA selectively inhibit the activities of PI3K isoforms and are therefore useful in therapeutic treatments, in particular in the treatment of cancer and inflammatory conditions.
(FR)La présente invention concerne des composés de formule I ou IA ou des sels pharmaceutiquement acceptables, des isomères, un tautomère, ou un mélange de ceux-ci, où s, t, m, n, R1, R2, R3, R4, R5, R6 et R7 sont tels que décrits dans la description. Les composés de formule I ou IA inhibent sélectivement les activités des isoformes de PI3K et sont par conséquent utiles dans des traitements thérapeutiques, en particulier dans le traitement du cancer et d'états inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)