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1. (WO2018057782) METHODS OF PREVENTING STEM CELL DIFFERENTIATION USING A PASK INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/057782 International Application No.: PCT/US2017/052781
Publication Date: 29.03.2018 International Filing Date: 21.09.2017
IPC:
C12N 5/071 (2010.01) ,C12N 5/073 (2010.01) ,C12N 5/0735 (2010.01) ,C12N 5/0775 (2010.01) ,C12N 5/0797 (2010.01)
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION[US/US]; 615 Arapeen Drive Suite 310 Salt Alke City, UT 84108, US
Inventors: RUTTER, Jared; US
KIKANI, Chintan, K.; US
Agent: MARTY, Scott D.; US
KATZ, Mitchell, A.; US
SHORTELL, D., Brian; US
HATHCOCK, Kevin, W.; US
MEADOWSA, Brian, C.; US
Priority Data:
62/398,59623.09.2016US
Title (EN) METHODS OF PREVENTING STEM CELL DIFFERENTIATION USING A PASK INHIBITOR
(FR) MÉTHODES DE PRÉVENTION DE LA DIFFÉRENCIATION DE CELLULES SOUCHES À L'AIDE D'UN INHIBITEUR DE PASK
Abstract: front page image
(EN) Described herein are methods of preventing or inhibiting differentiation of cells (e.g., stem cells and progenitor cells). The methods include contacting cells (e.g., stem cells and progenitor cells) with a PAS domain containing protein kinase (PASK) inhibitor. The cells produced provide a useful method of treating or preventing diseases or disorders such as disease-associated sarcopenia or stem cell loss disorders.
(FR) La présente invention concerne des méthodes de prévention ou d'inhibition de la différenciation de cellules (par exemple, des cellules souches et des cellules progénitrices) Les méthodes comprennent la mise en contact de cellules (par exemple, des cellules souches et des cellules progénitrices) avec un inhibiteur de protéine kinase contenant un domaine PAS (PASK). Les cellules produites fournissent une méthode utile de traitement ou de prévention de maladies ou de troubles tels que la sarcopénie associée à une maladie ou des troubles de la perte de cellules souches.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)