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1. (WO2018057779) COMPOSITIONS OF SYNTHETIC TRANSPOSONS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/057779    International Application No.:    PCT/US2017/052776
Publication Date: 29.03.2018 International Filing Date: 21.09.2017
IPC:
C12N 15/10 (2006.01), C12Q 1/68 (2006.01)
Applicants: ZHENG, Jianbiao [US/US]; (US)
Inventors: ZHENG, Jianbiao; (US)
Agent: QI, Yan; (US).
AIKEN, Charity; (US).
AHN, Sejin; (US).
BANKO, Max; (US).
ARJOMAND, Mehran; (US)
Priority Data:
62/399,188 23.09.2016 US
Title (EN) COMPOSITIONS OF SYNTHETIC TRANSPOSONS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS DE TRANSPOSONS SYNTHÉTIQUES ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention provides synthetic transposons having two non-complementary regions comprising adapter sequences and linked to each other. The synthetic transposons may further comprise molecular barcodes. Also disclosed are compositions comprising a plurality of the synthetic transposons, methods, and kits for library preparation. The compositions, methods, kits and analysis tools described herein have many applications, including high-quality sequencing, haplotyping, error correction, sequencing of repetitive regions, detection of structural variations and copy number variations, methylation analysis and quantification of target nucleic acids.
(FR)La présente invention concerne des transposons synthétiques ayant deux régions non complémentaires comprenant des séquences d'adaptateur et liées l'une à l'autre. Les transposons synthétiques peuvent en outre comprendre des codes-barres moléculaires. L'invention concerne également des compositions comprenant une pluralité de transposons synthétiques, des procédés et des kits pour la préparation de bibliothèques. Les compositions, les procédés, les kits et les outils d'analyse décrits ici ont de nombreuses applications, y compris le séquençage de haute qualité, l'haplotypage, la correction d'erreurs, le séquençage de régions répétitives, la détection de variations structurales et de variations du nombre de copies, l'analyse de méthylation et la quantification d'acides nucléiques cibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)