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1. (WO2018057755) HIGH MOBILITY GROUP BOX I MUTANT

Pub. No.:    WO/2018/057755    International Application No.:    PCT/US2017/052746
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Fri Sep 22 01:59:59 CEST 2017
IPC: A61K 31/00
A61K 31/496
A61K 31/5025
Applicants: THORNE, Stephen H.
Inventors: THORNE, Stephen H.
Title: HIGH MOBILITY GROUP BOX I MUTANT
Abstract:
This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein. It provides, at least in part, that vaccinia viruses modified to contain nucleic acid encoding variant HMGB1 and that express a variant HMGB1 or a fragment thereof can achieve a synergistic effect in combination with chemotherapy. Further, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of various cancers.