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1. (WO2018057550) COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/057550    International Application No.:    PCT/US2017/052378
Publication Date: 29.03.2018 International Filing Date: 20.09.2017
IPC:
A61K 31/381 (2006.01), A61K 31/44 (2006.01), A61K 31/4436 (2006.01)
Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnett Avenue Cincinnati, OH 45229 (US)
Inventors: KALINICHENKO, Vladimir; (US).
KALIN, Tatiana; (US)
Agent: TEPE, Nicole M.; (US)
Priority Data:
62/396,992 20.09.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Disclosed are methods and compositions for the treatment of a proliferative disorder characterized by increased expression of the FOXMl gene. Exemplary disorders include adenocarcinoma, melanoma, rhabdomyosarcoma, non-small cell lung cancer (NSCLC), head and neck squamous carcinoma, hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, colon carcinoma, basal cell carcinoma, infiltrating ductal breast carcinoma, anaplastic astrocytoma, glioblastoma, pancreatic carcinoma, gastric cancer, acute myeloid leukemia, lung cancer, liver cancer, breast cancer, prostate cancer, a brain cancer. Kits and articles of manufacture comprising compositions for such treatment are also disclosed.
(FR)L'invention concerne des méthodes et des compositions pour le traitement de maladies prolifératives caractérisées par une augmentation de l'expression du gène FOXMl. Des exemples de telles maladies comprennent l'adénocarcinome, le mélanome, le rhabdomyosarcome, le carcinome pulmonaire non à petites cellules (CPNPC), le carcinome spinocellulaire de la tête et du cou, le carcinome hépatocellulaire (CHC), le cholangiocarcinome intrahépatique, le carcinome du côlon, le carcinome basocellulaire, le carcinome canalaire du sein infiltrant, l'astrocytome anaplasique, le glioblastome, le carcinome pancréatique, le cancer de l'estomac, la leucémie myéloïde aiguë, le cancer du poumon, le cancer du foie, le cancer du sein, le cancer de la prostate, la tumeur du cerveau. L'invention concerne également des kits et articles manufacturés comprenant les compositions pour un tel traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)