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1. (WO2018057522) HARNESSING PROTEIN-BASED DRUGS COMPRISING AN ANCHOR DOMAIN FOR USE ON THE OCULAR SURFACE

Pub. No.:    WO/2018/057522    International Application No.:    PCT/US2017/052288
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Wed Sep 20 01:59:59 CEST 2017
IPC: C12N 15/62
A61K 38/56
A61K 39/395
A61P 27/02
Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
SHANKS, Robert, Michael Queen
KLARLUND, Jes, K.
Inventors: SHANKS, Robert, Michael Queen
KLARLUND, Jes, K.
Title: HARNESSING PROTEIN-BASED DRUGS COMPRISING AN ANCHOR DOMAIN FOR USE ON THE OCULAR SURFACE
Abstract:
Pharmaceutical compositions are disclosed including an effective amount of a fusion protein that contains an anchor domain and a therapeutic polypeptide for use in treating a disorder that affects the eye (e.g., corneal haze or scarring, dry eye disease, and inflammation of an ocular surface). Fusion proteins are disclosed that includes an anchor domain and a therapeutic polypeptide. Some embodiments include an isolated nucleic acid molecule that can encode the fusion protein. Methods are also disclosed for treating a subject with a disorder that affects the eye (e.g., corneal haze or scarring, dry eye disease, and inflammation of an ocular surface) that includes administering to the eye of the subject a therapeutically effective amount of the fusion protein disclosed herein.