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1. (WO2018057201) SURFACE ACOUSTIC WAVE BIOSENSOR EMPLOYING AN ANALOG FRONT END AND DNA ENCODED LIBRARIES TO IMPROVED LIMIT OF DETECTION (LOD) WITH EXEMPLARY APPARATUS OF THE SAME
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Pub. No.:
WO/2018/057201
International Application No.:
PCT/US2017/048055
Publication Date:
29.03.2018
International Filing Date:
22.08.2017
IPC:
G01N 29/00
(2006.01)
G
PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
29
Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
Applicants:
SENSOR KINESIS CORP.
[US/US]; 6053 W. Century Blvd Ste 1000 Los Angeles, California 90045 (US)
Inventors:
SHACHAR, Yehoshua
; (US).
KORNBERG, Roger
; (US)
Agent:
DAWES, Daniel
; (US).
DAWES, Marcus
; (US)
Priority Data:
62/397,233
20.09.2016
US
Title
(EN)
SURFACE ACOUSTIC WAVE BIOSENSOR EMPLOYING AN ANALOG FRONT END AND DNA ENCODED LIBRARIES TO IMPROVED LIMIT OF DETECTION (LOD) WITH EXEMPLARY APPARATUS OF THE SAME
(FR)
BIOCAPTEUR À ONDES ACOUSTIQUES DE SURFACE UTILISANT UN FRONTAL ANALOGIQUE ET DES BANQUES CODÉES D’ADN POUR AMÉLIORER LA LIMITE DE DÉTECTION (LOD) AVEC UN APPAREIL EXEMPLAIRE DE CELUI-CI
Abstract:
(EN)
A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.
(FR)
Une onde acoustique de surface (SAW) effectue une détection rapide, sans marqueur, d’espèces biologiques. La biodétection et la détection d’analytes multiples multiplexées par une matrice de lignes de détection sont configurées pour permettre une bio-amplification au moyen de banques codées d’ADN modifié en tant que sonde par l’intermédiaire d’une procédure de présentation sur phage pour améliorer la spécificité, des statistiques de capture pour la détection, le criblage et l’analyse de l’analyte in vitro. Une formulation biochimique réduit au minimum la limite de détection (LOD) à une amplitude seuil de l’ordre d’une concentration femtomolaire. Une amélioration supplémentaire de l’appareil est obtenue au moyen d’un frontal analogique pour amplifier des événements biochimiques.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)