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1. (WO2018056865) PHARMACEUTICAL COMPOSITION FOR TREATING HIV INFECTION

Pub. No.:    WO/2018/056865    International Application No.:    PCT/RU2017/000622
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Sat Aug 26 01:59:59 CEST 2017
IPC: A61K 31/513
A61K 31/427
A61K 47/32
A61K 47/34
A61K 9/20
A61P 31/18
Applicants: LIMITED LIABILITY COMPANY IZVARINO PHARMA
ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ ИЗВАРИНО ФАРМА
Inventors: KHAZANOVA, Elena Sergeevna
ХАЗАНОВА, Елена Сергеевна
NOGAI, Sergei Urevich
НОГАЙ, Сергей Юрьевич
IAKOVLEV, Dmitrii Vladimirovich
ЯКОВЛЕВ, Дмитрий Владимирович
Title: PHARMACEUTICAL COMPOSITION FOR TREATING HIV INFECTION
Abstract:
The invention relates to the field of the pharmaceutical chemical industry. The present pharmaceutical composition for treating HIV infection comprises lopinavir and ritonavir in an effective amount, and a polymer. The pharmaceutical composition is produced by extrusion. The composition comprises, as the polymer, a matrix polymer consisting of PEG 6000 / vinylcaprolactam / vinyl acetate, at 5 to 25 % of the mass of the pharmaceutical composition, in combination with copovidone, at 45 to 65 % of the mass of the pharmaceutical composition. This invention makes it possible to broaden the range of available drugs with improved pharmacokinetic properties.