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1. (WO2018056824) MANIPULATION OF IMMUNE ACTIVITY BY MODULATION OF EXPRESSION - STUB1
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/056824    International Application No.:    PCT/NL2017/050639
Publication Date: 29.03.2018 International Filing Date: 25.09.2017
IPC:
G01N 33/50 (2006.01), G01N 33/564 (2006.01), G01N 33/574 (2006.01), C12Q 1/527 (2006.01)
Applicants: STICHTING HET NEDERLANDS KANKER [NL/NL]; Instituut-Antoni van Leeuwenhoek Ziekenhuis 121, Plesmanlaan 1066 CX AMSTERDAM (NL)
Inventors: SCHUMACHER, Antonius Nicolaas Maria; (NL).
BRUMMELKAMP, Thijn Reinout; (NL).
SUN , Chong; (NL).
JAE , Lucas Tilmann; (NL).
MEZZADRA, Riccardo Ernesto; (NL)
Agent: ALGEMEEN OCTROOI- EN MERKENBUREAU B.V.; P.O. Box 645 5600 AP Eindhoven (NL)
Priority Data:
2017523 23.09.2016 NL
2019271 18.07.2017 NL
2019281 19.07.2017 NL
Title (EN) MANIPULATION OF IMMUNE ACTIVITY BY MODULATION OF EXPRESSION - STUB1
(FR) MANIPULATION DE L'ACTIVITÉ IMMUNITAIRE PAR MODULATION DE L'EXPRESSION DE STUB1
Abstract: front page image
(EN)The present invention relates to the field of immunity, immune activity and more particularly to the field of "immune check points" including the PD-1/PD-L1 axis, and conditions or diseases involving PD-1/PD-L1 axis signaling. Provided are modulators of immune activity, which modulators influence the activity and/or expression of STUB1.
(FR)L'invention concerne le domaine de l'immunité, l'activité immunitaire et plus particulièrement le domaine des "points de contrôle immunitaires", notamment l'axe PD-1/PD-L1, ainsi que les affections ou maladies impliquant la signalisation de l'axe PD-1/PD-L1. L'invention concerne en particulier des modulateurs de l'activité immunitaire, ces modulateurs influençant l'activité et/ou l'expression de STUB1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)