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1. (WO2018056746) SWEET-TASTING PROTEIN BRAZZEIN VARIANT HAVING ANTIALLERGIC ACTIVITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/056746 International Application No.: PCT/KR2017/010465
Publication Date: 29.03.2018 International Filing Date: 22.09.2017
IPC:
A61K 38/16 (2006.01) ,A61K 8/64 (2006.01) ,A23L 33/18 (2016.01) ,A61Q 19/00 (2006.01)
Applicants: BIOSWEET CO., LTD.[KR/KR]; (Munjeong Daemyeong Valeon, Munjeong-dong)415, 127, Beobwon-ro, Songpa-gu, Seoul 05836, KR
Inventors: KONG, Kwang Hoon; KR
JUNG, Ju Hee; KR
YUN, Cho Rong; KR
KIM, Da Hye; KR
KIM, Jun O; KR
Agent: DANA PATENT LAW FIRM; 5th Floor, New Wing, Gwangsung Bldg., 11, Yeoksam-ro 3-gil, Gangnam-gu, Seoul 06242, KR
Priority Data:
10-2016-012202023.09.2016KR
Title (EN) SWEET-TASTING PROTEIN BRAZZEIN VARIANT HAVING ANTIALLERGIC ACTIVITY
(FR) VARIANT À GOÛT SUCRÉ DE LA PROTÉINE BRAZZÉINE POSSÉDANT DES PROPRIÉTÉS ANTIALLERGIQUES
(KO) 항알러지 활성을 갖는 감미 단백질 브라제인 변이체
Abstract: front page image
(EN) The present invention relates to a brazzein multiplex variant having antiallergic and antioxidative activities and, more specifically, to a brazzein multiplex variant capable of simultaneously exhibiting both an antioxidative effect through GST and tyrosinase activities and an antiallergic effect through an inhibitory activity against the release of β-hexosaminidase, which is a degranulation-indicating substance, released with histamine. Accordingly, the brazzein multiplex variant according to the present invention can be usefully employed in a pharmaceutical composition for allergic disease prevention or treatment, an antiallergic cosmetic composition, an antioxidative composition, an antioxidative cosmetic composition, and a health functional food.
(FR) La présente invention concerne un variant multiplex de la brazzéine possédant des propriétés antiallergiques et antioxydantes et, plus spécifiquement, à un variant multiplex de la brazzéine capable de présenter simultanément à la fois un effet antioxydant, par le biais d'activités GST et tyrosinase, et un effet antiallergique passant par une activité inhibitrice de la libération de la β-hexosaminidase, qui est un marqueur de la dégranulation libéré parallèlement à l'histamine. Par conséquent, le variant multiplex de la brazzéine de la présente invention peut être utilisé avantageusement dans une composition pharmaceutique destinée à la prévention ou au traitement de maladies allergiques, dans une composition cosmétique antiallergique, une composition antioxydante, une composition cosmétique antioxydante, et un aliment fonctionnel de santé.
(KO) 본 발명은 항알러지 및 항산화 활성을 가지는 브라제인 다중 변이체에 관한 것으로, 더욱 상세하게는 브라제인 다중 변이체는 GST 효소 활성 및 티로시나아제 효소 활성을 통한 항산화 효과뿐만 아니라, 히스타민과 함께 분비되는 탈과립 지표 물질인 베타-헥소사민다제(β-hexosaminidase)의 분비 저해 활성을 통한 항알러지 효과를 동시에 나타낼 수 있다. 따라서, 본 발명의 브라제인 다중 변이체는 알러지 질환 예방 또는 치료용 약제학적 조성물, 항알러지 화장료 조성물, 항산화 조성물, 항산화 화장료 조성물 및 건강기능식품으로 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)