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1. (WO2018056620) COMBINED COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING A BENZOPHENONE THIAZOLE DERIVATIVES AS A VDA AND TOPOISOMERASE INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/056620    International Application No.:    PCT/KR2017/009889
Publication Date: 29.03.2018 International Filing Date: 08.09.2017
IPC:
A61K 31/4741 (2006.01), A61K 45/06 (2006.01)
Applicants: CHONG KUN DANG PHARMACEUTICAL CORP. [KR/KR]; 8 Chungjeong-ro, Seodaemun-gu, Seoul 03742 (KR).
NATIONAL CANCER CENTER [KR/KR]; 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408 (KR)
Inventors: KIM, Soo Jin; (KR).
KIM, Young Sang; (KR).
KIM, Minchae; (KR).
PARK, Young-Whan; (KR).
KIM, Jung-Yong; (KR).
KIM, In Chull; (KR)
Agent: YOU ME PATENT AND LAW FIRM; 115 Teheran-ro Gangnam-gu Seoul 06134 (KR)
Priority Data:
62/400,054 26.09.2016 US
15/447,247 02.03.2017 US
Title (EN) COMBINED COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING A BENZOPHENONE THIAZOLE DERIVATIVES AS A VDA AND TOPOISOMERASE INHIBITOR
(FR) COMPOSITION COMBINÉE POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER COMPRENANT DES DÉRIVÉS DE BENZOPHÉNONE THIAZOLE EN TANT QUE VDA ET UN INHIBITEUR DE TOPO-ISOMÉRASE
Abstract: front page image
(EN)The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof and topoisomerase inhibitor as active ingredients. The pharmaceutical combined composition of the present invention specifically inhibits cell proliferation and induces apoptosis as to various cancers such as colorectal cancer and ovarian cancer that a vascular disrupting agent cannot treat due to a complex inhibition mechanism of neoplasm of the compound of formula 1 and the pharmaceutically acceptable salt thereof and topoisomerase inhibitor, and thereby it can be usefully used for preventing and treating cancer.
(FR)La présente invention concerne une composition pharmaceutique combinée pour la prévention ou le traitement du cancer comprenant un composé de formule I ou un sel pharmaceutiquement acceptable de celui-ci et un inhibiteur de la topo-isomérase en tant que principes actifs. La composition pharmaceutique combinée de la présente invention inhibe spécifiquement la prolifération cellulaire et induit l'apoptose pour divers cancers tels que le cancer colorectal et le cancer de l'ovaire qu'un agent de perturbation vasculaire ne peut pas traiter, grâce au mécanisme d'inhibition complexe du néoplasme du composé de formule I et de son sel pharmaceutiquement acceptable et de l'inhibiteur de topo-isomérase, et par conséquent il peut être utilisé de manière utile pour prévenir et traiter le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)