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1. (WO2018056361) NOVEL ALKYLATING AGENT

Pub. No.:    WO/2018/056361    International Application No.:    PCT/JP2017/034121
Publication Date: Fri Mar 30 01:59:59 CEST 2018 International Filing Date: Fri Sep 22 01:59:59 CEST 2017
IPC: C07D 403/14
A61K 31/403
A61P 35/00
A61P 43/00
C12N 15/09
C12Q 1/68
Applicants: CHIBA-PREFECTURE
千葉県
Inventors: NAGASE Hiroki
永瀬 浩喜
HATTORI Asuka
服部 あすか
WATANABE Takayoshi
渡部 隆義
TAKATORI Atsushi
高取 敦志
Title: NOVEL ALKYLATING AGENT
Abstract:
The purpose of the present invention is to provide a novel alkylating agent that binds specifically to immune checkpoint genes, that induces cell death, and that has a tumor-specific aggregating property. Provided are: a complex which specifically binds to genes that encode immune checkpoint molecules, and which includes an alkylating agent bonded to a polyamide; an alkylating agent that includes the complex, and that is specific to genes encoding immune checkpoint molecules; and a pharmaceutical composition including the complex.