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1. (WO2018056301) CANCER STEM CELL INHIBITOR AND USE THEREOF
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Pub. No.: WO/2018/056301 International Application No.: PCT/JP2017/033890
Publication Date: 29.03.2018 International Filing Date: 20.09.2017
IPC:
A61K 45/00 (2006.01) ,A61K 31/353 (2006.01) ,A61K 39/00 (2006.01) ,A61P 1/18 (2006.01) ,A61P 11/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
18
for pancreatic disorders, e.g. pancreatic enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 福岡県福岡市東区箱崎六丁目10番1号 6-10-1, Hakozaki, Higashi-ku, Fukuoka-shi, Fukuoka 8128581, JP
Inventors:
立花 宏文 TACHIBANA Hirofumi; JP
Agent:
棚井 澄雄 TANAI Sumio; JP
松沼 泰史 MATSUNUMA Yasushi; JP
及川 周 OIKAWA Shu; JP
飯田 雅人 IIDA Masato; JP
Priority Data:
2016-18469221.09.2016JP
Title (EN) CANCER STEM CELL INHIBITOR AND USE THEREOF
(FR) INHIBITEUR DE CELLULES SOUCHES CANCÉREUSES ET SON UTILISATION
(JA) 癌幹細胞阻害剤及びその使用
Abstract:
(EN) Provided is a cancer stem cell inhibitor containing, as an active ingredient, an inhibitor of the forkhead box O3 (FOXO3)/liver kinase B1 (LKB1)/PPARγ coactivator 1β (PGC-1β)/pyruvate dehydrogenase α1 (PDHA1)/membrane associated ring-CH-type finger 8 (MARCH8) pathway.
(FR) L'invention concerne un inhibiteur de cellules souches cancéreuses contenant, en tant que principe actif, un inhibiteur de la voie de signalisation de la tête de fourche, boîte O3 (FOXO3)/kinase hépatique B1 (LKB1)/coactivateur PPARy 1β (PGC-1β)/pyruvate déshydrogénase α1 (PDHA1)/Ring-CH 8 associé à la membrane (MARCH8).
(JA) Forkhead box O3(FOXO3)/Liver kinase B1(LKB1)/PPARγ coactivator 1β(PGC-1β)/Pyruvate dehydrogenase α1(PDHA1)/Membrane associated ring-CH-type finger 8(MARCH8)経路の阻害剤を有効成分として含有する、癌幹細胞阻害剤。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)