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1. (WO2018055145) PREDICTING RESPONSE TO PD-1 AXIS INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/055145    International Application No.:    PCT/EP2017/074150
Publication Date: 29.03.2018 International Filing Date: 25.09.2017
IPC:
G01N 33/574 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (For All Designated States Except US).
HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department Little Falls, New Jersey 07424 (US) (US only)
Inventors: KLEIN, Christian; (CH).
MAYOUX, Maud Léa; (CH).
ROLLER, Andreas; (CH).
XU, Wei; (CH)
Agent: BRODBECK, Michel; (CH)
Priority Data:
16190591.4 26.09.2016 EP
17166789.2 18.04.2017 EP
Title (EN) PREDICTING RESPONSE TO PD-1 AXIS INHIBITORS
(FR) PRÉDICTION DE RÉACTION À DES INHIBITEURS DE L'AXE PD-1
Abstract: front page image
(EN)The invention is concerned with a method of predicting response to a PD-1 axis inhibitor such as anti-PD-L1 antibody by determing the abundance of dendritic cells (DCs) in a tumor tissue sample. The abundance of DCs characterized by enhanced expressions of XCR1, IRF8, BATF3 and FLT3 predicts clinical response to the PD-L1 blockade treatment.
(FR)L'invention concerne un procédé de prédiction de réaction à un inhibiteur de l'axe PD-1, tel qu'un anticorps anti-PD-L1, par détermination de l'abondance de cellules dendritiques (CD) dans un prélèvement de tissu tumoral. L'abondance de CD caractérisée par des expressions accrues de XCR1, d'IRF8, de BATF3 et de FLT3 prédit une réaction clinique au traitement par blocage de PD-L1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)